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>97% by SDS-PAGE and HPLC analyses
111:181-196
ELISA Data: Immobilized Rhesus macaque Latent TGF beta 1
356 μM as determined in SPR assay
Comprehensive validation – Fully validated according to ICH Q2 (R2) guidelines
SB-431542 _ 53004ES Tumor Necrosis Factor(TNFR) >97% by SDS-PAGE and HPLCSB 431542 (SB431542), a known Src family kinase inhibitor, is also a potent and selective inhibitor of ALK5 (IC50: 94 nM) and ALK4 (IC50: 140 nM). SB 431542 inhibits the TGF mediated activation of SMAD proteins, expression of collagen and fibronectin, cell proliferation and cell motility, and effectively blocks the transforming growth factor 1 induced cell migration and invasion. Features Purity98% Standardized production, using factory mass
