Just looking at the maindeck, you are countering at least 12 of their non-negotiable slots (Glistener Elf, Noble Hierarch, and Vines of Vastwood), along with some number of Growth, Might of Old Krosa, Groundswell, etc
Otherwise, you gain control of target permanent they control
On the bright side, WotC is always finding new ways to make mill more viable in EDH
Those were snapshots from before Sets 5-8 left Core Constructed on July 17, the same day as the Set 13 prerelease
Your opponent is going to have countermeasures, and by diversifying your sideboard package you force them to diversify those countermeasures, which means bringing in more cards than they would like and cutting into their core pieces
My collection is several thousand cards (small to some, decent to others), and not worth much in the end to anyone but me and other weird collectors like myself, so basic protection is fine