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Enigma Thief Interacting with all opponents at once is the name of the game in Commander

3 The Ur-Dragon It's not hard to see why The Ur-Dragon is so popular

Honorable Mentions Legendary Creatures Rubinia Soulsinger seems to be so Commander-friendly that it was even reprinted in Commander 2013

This turns the deck more from a sacrificing and destroying-focused amass strategy into a spellslinging one, with Saruman amassing every time you cast a noncreature spell

Probably all the others combined, in fact

Your most comprehensive form of instant speed protection is Teferi's Protection which not only keeps your board safe, but also stops most forms of interaction with you until your next turn