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This might not matter in 99.9% of cases, but the 0.1% of the time where you want to cast it on a Thassa's Oracle trigger against a player with an Esper Sentinel to make them deck themselves, it will matter a lot

While that's not the most terrible idea, the likelihood in a Niv-Mizzet deck is that the other spell you're casting is a burn spell that could do the same, and I have to feel that you're going to be better off casting it by itself, rather than putting all your eggs in one basket

Ive seen the king of heart being a Victreebel on 2 yellow decks and being a Vileplume on a blue deck

Instants are spells you can cast at almost any time

Admit it

Also, theyre chocobos