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If you have a card that turns effect damage into life gain like Intervention Pact or Samite Ministration, you can pick an absurd number like ten trillion and gain that much life

I started with Mono White just to make things simple, but a blue/white build might also be very impactful

"Krawler" monsters this card points to cannot be destroyed by battle, gain 300 ATK/DEF, and can make up to 2 attacks on monsters during each Battle Phase

If not answered immediately, Cloudshredder Sliver can lead to some massive swings

Whenever a player casts an instant or sorcery spell, you draw a card.

Target Removal Kibo, Uktabi Prince is also a repeatable artifact removal