Azide-Hexanoyl-Val-Cit-PAB(m-PEG8)-MMAE Size:5mg S)-AHPC-acetamido-O-PEG6-C1-acid Synonyms CAS Number n/a

S)-AHPC-acetamido-O-PEG6-C1-acid Synonyms CAS Number n/a Related CAS Molecular Formula C38H58N4O13S Molecular Weight 810

which recruit the VHL or CRBN-ubiquitin E3 ligases to induce the degradation of SNAP-fusion proteins

292 Purity (HPLC) >= 95% Solubility DMSO

443 SMILES CC(C)(C)OC(=O)CN1CCN(CC2CCNCC2)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Trametinib binds KRS-MEK and disrupts RAF-MEK

Azide-Hexanoyl-Val-Cit-PAB(m-PEG8)-MMAE Size:5mg S)-AHPC-acetamido-O-PEG6-C1-acid Synonyms CAS Number n/aSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing