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Rational discovery of molecular glue degraders via scalable chemical profiling
Product Name Thalidomide-propargyl-OH Synonyms Thalidomide-4'-propargyl-OH CAS Number 1216805-67-2 Related CAS Molecular Formula C16H12N2O5 Molecular Weight 312
Product Name Mal-Propionyl-PEG8-Val-Cit-PAB(m-PEG4)-PNP Synonyms CAS Number Related CAS Molecular Formula C61H95N9O24 Molecular Weight 1338
good photostability
Product Name Thalidomide-O-PEG3-C2-Cl Synonyms Thalidomide-4'-O-PEG3-C2-Cl CAS Number n/a Related CAS Molecular Formula C21H25ClN2O8 Molecular Weight 468
Mal-Propionyl-PEG6-Val-Cit-PAB(m-PEG4) Size:10mg Rational discovery of molecular glueSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX
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