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Mal-Propionyl-PEG8-Val-Ala-PAB(m-PEG4)-Exatecan probe Ceccarelli

SKU: 89525256422

4.4
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Description

Ceccarelli

392 Purity (HPLC) >= 95% Solubility DMSO

Biotin-labeled biomolecules can be bound to avidin or streptavidin for further purification and detection

Product Name DOTA-PEG3-propargyl Synonyms CAS Number n/a Related CAS Molecular Formula C25H43N5O10 Molecular Weight 573

Product Name Thalidomide-O-PEG1-propargyl Synonyms Thalidomide-4'-O-PEG1-propargyl CAS Number 2098487-79-5 Related CAS Molecular Formula C18H16N2O6 Molecular Weight 356

Mal-Propionyl-PEG8-Val-Ala-PAB(m-PEG4)-Exatecan probe CeccarelliSOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I

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