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Mal-Propionyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG4)-MMAE Size:5mg O=C(COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1)N1CCNCC1 Purity (HPLC): 95% Shipping

SKU: 87548068708

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Description

O=C(COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1)N1CCNCC1 Purity (HPLC): 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

Westermann

HQ461-mediated degradation of cyclin K impairs CDK12 function

DiAcFAM ( diacetylfluorescein

338 SMILES OCCOCCOC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG4)-MMAE Size:5mg O=C(COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1)N1CCNCC1 Purity (HPLC): 95% ShippingSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is

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