Propargyl-Gly(m-PEG4)-Val-Cit-PAB(m-PEG8) dota Product Name: 5(6)-TAMRA PEG3 azide

Product Name: 5(6)-TAMRA PEG3 azide Synonyms: 5/6-Carboxytetramethylrhodamine-PEG3-Azide CAS Number: 604810-60-8 Molecular Formula: C33H38N6O7 Molecular Weight: 630

544 SMILES [N-]=[N+]=NCCOCCOCCOCCOCCNC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

the reaction product is stable

235 SMILES BrCCCC(=O)NC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Trametinib binds KRS-MEK and disrupts RAF-MEK

Propargyl-Gly(m-PEG4)-Val-Cit-PAB(m-PEG8) dota Product Name: 5(6)-TAMRA PEG3 azideSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. Derived