Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan only Mukhopadhyay

Mukhopadhyay

79 SMILES: CC1(C)\C(=C/C=C/C2=[N+](CCCCCC(=O)OCC#C)C3=CC=CC=C3C2(C)C)N(CCCS([O-])(=O)=O)C2=CC=CC=C12 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

COA          MSDS

803 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCOCCOCCOCCOCCOCC#C)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

338 SMILES OC(=O)CCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan only MukhopadhyaySOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is