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"Effect of chemical modifications on aptamer stability in serum
Liping Zhong
"The MOE modification of RNA: Origins and widescale impact on the oligonucleotide therapeutics field
or 10 min at 65 °C in AMA (ammonia/methylamine
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DMT-2'-O-TBDMS-C(Ac)-CE Phosphoramidite RNA (2'-O-TBDMS) Phosphoramidites "Effect of chemical modifications onDMT 2' O TBDMS C(Ac) CE Phosphoramidite is a protected ribonucleoside building block used for solid phase RNA oligonucleotide synthesis. It contains a 5' dimethoxytrityl (DMT) protecting group for 5' hydroxyl protection, a 2' O tert butyldimethylsilyl (TBDMS) protecting group for 2' hydroxyl protection, a cyanoethyl (CE) protecting group on phosphite, and a acetyl (Ac) base protecting group on cytosine. TBDMS offers excellent stability for protecting
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