5-FAM alkyne halide Degrader building block for targeted

Degrader building block for targeted protein degradation

uorescence of the acetylene – tetramethylrhodamine conjugate as well as of many other rhodamine based probes is pH insensitive between 4 and 9

they are quite unstable in water

It is preferred for some complicated biological applications where reproducibility is critical since the minor positional difference between 5-isomer and 6-isomer might have biological implications

364 SMILES OC(=O)CCOCCNC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

5-FAM alkyne halide Degrader building block for targeted5 FAM alkyne is an excellent azide reactive fluorescent reagent for labeling alkyne containing biological molecules through click chemitry. Click chemistry describes a class of chemical reactions that use bio orthogonal or biologically unique moities to label and detect a molecule of interest using a two step procedure. The two step reaction procedure involves a copper catalyzed triazole formation of an azide and an alkyne. Click reactions have