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Azide and alkyne groups do not react or interfere with other functional groups found in biological samples but conjugate to one another with high efficiency
The inhibiting SHP2 activity of SHP099 is through an allosteric mechanism
The Mal-Propionyl group may also improve retro-Michael addition stability during antibody conjugation
RSC Medicinal Chemistry
43 SMILES: OC1=CC2=C(C=C1)C1(OC(=O)C3=CC(=CC=C13)C(=O)NCCCN=[N]#N)C1=CC=C(O)C=C1O2 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only
DOTA-tris(t-Bu)ester-PEG5-propargyl 5' Azide and alkyne groups doDOTA bifucational chelator containing an alkyne group, a PEG linker, and the macrocyclic chelator DOTA ( 1,4,7,10 tetraazacyclododecane 1,4,7,10 tetraacetic acid). It can be used in many different diagnostic and therapeutic applications, such as MRI contrast agents, PET and SPECT imaging agents, and radiotherapeutic agents. Product Name DOTA tris(t Bu)ester PEG5 propargyl Synonyms CAS Number n a Related CAS Molecular Formula C41H75N5O12 Molecular
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