Propargyl-Gly(m-PEG4)-Val-Ala-PAB(m-PEG8)-PNP PEG4 5(6)-TAMRA is the mixture of

5(6)-TAMRA is the mixture of two carboxy tetramethylrhodamine (TMR) isomers

486 Purity (HPLC) >= 95% Solubility DMSO

Rational discovery of molecular glue degraders via scalable chemical profiling

83 SMILES: [O-]S(=O)(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)S(=O)(=[OH+])NCCCN=[N]#N Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

95 SMILES Cl

Propargyl-Gly(m-PEG4)-Val-Ala-PAB(m-PEG8)-PNP PEG4 5(6)-TAMRA is the mixture ofSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The PNP