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Identification of a Novel Linker Enabling the Bioconjugation of a Cyclic Dinucleotide for the STING Antibody-Drug Conjugate TAK-500
Product Name Pomalidomide-C5-Br Synonyms Pomalidomide-4'-C5-Br CAS Number 2355289-70-0 Related CAS Molecular Formula C18H20BrN3O4 Molecular Weight 422
Sulfo-CA-Lissamine Rhodamine B is a sulfonated HaloTag substrate featuring a sulfonate group on the amide bond linking the chloroalkane moiety to the Lissamine Rhodamine B dye
275 (2024) paper studing DCAF1-based PROTACs
Product Name DOTA-tris(t-Bu)ester-PEG5-C2-propanamido-maleimide Synonyms CAS Number n/a Related CAS Molecular Formula C47H83N7O15 Molecular Weight 986
Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG4)-MMAE Size:25mg Identification of a Novel LinkerSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly
