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Mal-Propionyl-PEG6-Val-Ala-PAB(m-PEG4)-Exatecan Size:5mg 4 Purity (HPLC) >= 95%

SKU: 44248023567

4.3
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Description

4 Purity (HPLC) >= 95% Solubility DMSO

molecular biology

Nitrogen Heterocycle Based Linker (NHBL)

956 Purity (HPLC) >= 95% Solubility DMSO

189 Purity (HPLC) >= 95% Solubility DMSO

Mal-Propionyl-PEG6-Val-Ala-PAB(m-PEG4)-Exatecan Size:5mg 4 Purity (HPLC) >= 95%SOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG6 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I

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