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and the commercial tetramethylrhodamine maleimides and iodoacetamides often have lower purities than other tetramethylrhodamine labeling reagents (such as TAMRA SE reagents) due to their synthetic difficulties
Science 2017
Product Name DOTA-PEG4-C2-amine Synonyms CAS Number 2090232-34-9 Related CAS Molecular Formula C26H50N6O11 Molecular Weight 622
411 SMILES OCCCCCCC1=CC=C2C(=O)N(CC2=C1)C1CCC(=O)NC1=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Mayor-Ruiz
Propargyl-Acetyl-Val-Cit-PAB(m-PEG8)-MMAE 5' and the commercial tetramethylrhodamine maleimidesSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing
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