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The methyl group is inert in this context and cannot undergo the nucleophilic substitution reaction that the chloroalkane relies on to bind the HaloTag protein
E7820 induce targeted degradation of the splicing factor RBM39 through recruitment of the E3 ubiquitin ligase CRL4DCAF15
O=C(COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1)N1CCNCC1 Purity (HPLC): 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only
S)-AHPC-CO-C5-acid Synonyms CAS Number 2162120-87-6 Related CAS Molecular Formula C29H40N4O6S Molecular Weight 572
Hormone Receptor-Positive
Azide-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg The methyl group is inertSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC
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