Mal-Propionyl-PEG8-Val-Ala-PAB(m-PEG4)-PNP snap 1 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCl)C(C)(C)C)C=C1 Purity (HPLC)

1 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCl)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

promoting ZBTB16 degradation by primarily engaging distinct structural degrons on CRBN-ZnF3 zinc finger domains

Carmichael

Product Name DOTA-tris(t-Bu)ester-PEG3-C2-azide Synonyms CAS Number n/a Related CAS Molecular Formula C36H68N8O10 Molecular Weight 772

Ready for conjugation to a target protein ligand to form PROTACs containing Lenalidomide as cereblon ligand

Mal-Propionyl-PEG8-Val-Ala-PAB(m-PEG4)-PNP snap 1 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCCl)C(C)(C)C)C=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating