Mal-Propionyl-PEG8-Val-Cit-PAB(m-PEG4)-PNP Size:100mg 492 SMILES O=C(COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1)NCCOCCOCCOCC#C Purity (HPLC)

492 SMILES O=C(COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1)NCCOCCOCCOCC#C Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name tert-butyl 2-{4-[(piperidin-4-yl)methyl]piperazin-1-yl}acetate Synonyms CAS Number n/a Related CAS Molecular Formula C16H31N3O2 Molecular Weight 297

677 SMILES: [O-]C(=O)C1=CC=C(C=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCC#C

577 Purity (HPLC) >= 95% Solubility DMSO

Product Name VHL-CLIP-5C Synonyms CAS Number N/A Related CAS N/A Molecular Formula C42H54N8O6S Molecular Weight 799 Purity (HPLC) >= 95% Solubility DMSO

Mal-Propionyl-PEG8-Val-Cit-PAB(m-PEG4)-PNP Size:100mg 492 SMILES O=C(COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1)NCCOCCOCCOCC#C Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating