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Mal-Acetyl-Beta-Ala-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE nhs and relatively pH-insensitive fluorescence

SKU: 12973048234

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Description

and relatively pH-insensitive fluorescence

E7820 induce targeted degradation of the splicing factor RBM39 through recruitment of the E3 ubiquitin ligase CRL4DCAF15

COA           MSDS

NCCOCCOCCOCCNC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

276 SMILES NCCN1CCN(CCN)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Mal-Acetyl-Beta-Ala-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE nhs and relatively pH-insensitive fluorescenceSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers

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