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You should either prepare some means of moving it or just give up on that idea

While other cards that discard your cards give you some immediate benefit on its own like summoning creatures, drawing cards, or also force your opponent to discard cards as well, One With Nothing has no direct benefit by itself and you need other cards to make use of it

Id run any of the 0 cost shields (except Kite Shield because it was power crept in 2010 by Accorders Shield)

Illvoi Operative's ability resolves before the spell that caused it to trigger

Of course, the problem with big creatures tends to be that big creatures cost a ton of mana

All four versions of Very Cryptic Command allows you to always have an answer for whatever your opponent is packing.